Anti-aquaporin-4 antibodies in Devic’s neuromyelitis optica: therapeutic implications
نویسندگان
چکیده
منابع مشابه
Anti-myelin Oligodendrocyte Glycoprotein in Aquaporin-4 Negative Neuromyelitis Optica Spectrum Disorder
Background: The absence of Aquaporin-4 Antibody (AQP4-Ab) in a fraction of the Neuromyelitis Optica Spectrum Disorder (NMOSD) patients has led to a search for other serologic markers. Myelin Oligodendrocyte Glycoprotein (MOG) is a protein component of the myelin sheets encapsulating the neural fibers. Objectives: We aimed to compare the presence and levels of anti-MOG (Ig-G) in a group of s...
متن کاملAnti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica.
OBJECTIVE Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system. Circulating autoantibodies (NMO-immunoglobulin [Ig]G) against astrocyte water channel aquaporin-4 (AQP4) cause complement- and cell-mediated astrocyte damage with consequent neuroinflammation and demyelination. Current NMO therapies, which have limited efficacy, include immunosuppression...
متن کاملAnti-aquaporin-4 antibodies in neuromyelitis optica: how to prove their pathogenetic relevance?
The discovery of a specific autoantibody response in neuromyelitis optica (NMO) patients, which selectively targets astrocytic end feet at the glia limitans1 and which is directed against the water channel aquaporin-4 (AQP-4)2 was a milestone in defining this disease entity and profoundly changed our view regarding its pathogenesis.3 Indirect evidence, coming from clinical observations and path...
متن کاملA Case of Neuromyelitis Optica (Devics' Disease)
ages; according to some authors more commonly young females. Pathologically the disease resembles disseminated sclerosis in that there is demyelinization of axis cylinders. The spinal cord shows such diffuse or multiple disseminated lesions. The optic nerves also present the same type of lesions. Clinically the disease is quite distinct from disseminated sclerosis. It is characterized by an acu...
متن کاملTherapeutic cleavage of anti-aquaporin-4 autoantibody in neuromyelitis optica by an IgG-selective proteinase.
Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system caused by binding of pathogenic IgG autoantibodies (NMO-IgG) to astrocyte water channel aquaporin-4 (AQP4). Astrocyte damage and downstream inflammation require NMO-IgG effector function to initiate complement-dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC). He...
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ژورنال
عنوان ژورنال: Therapeutic Advances in Neurological Disorders
سال: 2010
ISSN: 1756-2864,1756-2864
DOI: 10.1177/1756285610382478